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Santa Ana /ˌsæntə ˈænə/ (Spanish for “Saint Anne, Ana is a city in Orange County, California. It’s home to the Santa Ana Zoo, with its monkeys, mini-train and walk-through aviary. In a Mission Revival–style building, the Bowers Museum displays a large collection of Native American art. The Discovery Cube Orange County is a children’s museum with hands-on science exhibits. The Heritage Museum of Orange County features restored 1890s homes set amid gardens.

Santa Ana is in Southern California, adjacent to the Santa Ana River, about 10 miles (16 km) from the coast. Founded in 1869, the city is part of the Greater Los Angeles Area, the second largest metropolitan area in the United States, with almost 18 million residents in 2010. Santa Ana is a very densely populated city, ranking fourth nationally in that regard among cities of over 300,000 residents (trailing only New York City, San Francisco, and Boston). In 2011, Forbes ranked Santa Ana the fourth-safest city of over 250,000 residents in the United States. Santa Ana’s northwestern and southern edges are part of the two largest commercial clusters in Orange County: the Anaheim–Santa Ana edge city and the South Coast Plaza–John Wayne Airport edge city.

Santa Ana lends its name to the Santa Ana Freeway (I-5), which runs through the city. It also shares its name with the nearby Santa Ana Mountains, and the Santa Ana winds, which have historically fueled seasonal wildfires throughout Southern California  The current Office of Management and Budget (OMB) metropolitan designation for the Orange County Area is Santa Ana–Anaheim–Irvine, California.